Science to Practice: Will Gadolinium Chelates Be Replaced by Iron Chelates in MR Imaging?

Macrocyclic Versus Linear Gadolinium Chelates.

T he article “High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1weighted images: evaluation of the macrocyclic gadolinium-based contrast agent gadobutrol” by Radbruch et al provides critical new information regarding gadolinium deposition in the dentate nucleus. The conclusion, from a study of 30 patients, is that no signal intensity increase is seen with gadobutr...

Analytical interference in plasma iron determination reveals gadolinium vs. iron transmetallation with linear gadolinium chelates

Use of Iron Chelates

U s e of chelating agents--especially the new compound Fe 1 3 8 t o correct iron chlorosis by effectively supplying iron to plants has proved promising in a series of experiments. All plant species tested-but not all individual plants-responded to treatment, and some of the individuals within species did respond with retreatment. Treatment responses in the field have lasted from two to six mont...

Phosphonated chelates for nuclear imaging.

A series of bis-, tris- and tetra-phosphonated pyridine ligands is presented. In view of their potential use as chelates for radiopharmaceutical applications, the physico-chemical properties of the ligands and of their Co(II), Ni(II), Cu(II), and Zn(II) complexes were studied by means of potentiometry and UV-Vis absorption spectroscopy. The pKa values of the ligands and of the complexes, as wel...

Synthesis and Characterization of Iron Oxide Nanoparticles by Thermal Decomposition Method of Iron (III) Chelates

   Magnetic iron oxide nanoparticles have numerous applications in the biomedical field. This paper reports the preparation and properties of iron oxide nanoparticles synthesised by thermal decomposition method from iron chelates. The iron oxide nanoparticles were characterized by FTIR, powder XRD, VSM, SEM and TEM techniques. FTIR and powder XRD studies show that iron oxide was fo...